In the bowl of a stand mixer fitted with the dough hook, combine 2 1/2 cups flour, the instant yeast, and salt. Add the milk or water, honey, and 1 tablespoon butter. Knead on medium speed until the dough comes together, adding in additional flour as needed until the dough pulls away from the sides of the bowl and is smooth. Cover and let rise in a warm place for 30 minutes to 1 hour.

Preheat the oven to 375 degrees F. Line a baking sheet with parchment paper.

In a bowl, combine the granulated sugar and 1 teaspoon cinnamon.

On a floured surface, roll the dough out into a rectangle about 1/4 inch thick. Spread the dough with 4 tablespoons butter and sprinkle with cinnamon sugar. Fold the dough in half and cut into 12 strips. Twist each strip and then tie into a loose knot. Place on the prepared baking sheet.

Melt the remaining 2 tablespoons butter. Stir the melted butter together with the remaining 2 teaspoons cinnamon and the brown sugar. Spoon clumps of the brown sugar mix over the knots.

Transfer to the oven and bake for 8-10 minutes. Remove from the oven and carefully spoon any of the brown sugar that has melted off back over the rolls. Return to the oven and continue baking for another 8-10 minutes, until golden.

Meanwhile, make the glaze. In a medium bowl, beat together the powdered sugar, cream cheese, vanilla, and 2 tablespoons water until smooth and combined. If needed, thin the glaze by adding water, 1 tablespoon at a time, until the desired consistency is reached.

Drizzle glaze over the knots, if desired.